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___ of one's existence (biggest irritation)

On this page you may find the ___ of one's existence (biggest irritation) crossword puzzle clue answers and solutions. This crossword clue was last seen on May 1 2022 in the popular Daily Themed Crossword Puzzle. We have found 1 possible solution matching the query “___ of one's existence (biggest irritation)” and the answer is shown below.

The possible answer is:

BANE

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